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If oral B12 replacement has been trialled in a person with metformin-associated B12 deficiency, I would suggest that a repeat measurement of B12 levels after 812 weeks is a good time to reassess whether absorption is adequate or whether a switch to intramuscular replacement is required

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My understanding is that testing B12 during treatment is not normally needed

The Coenzyme Forms of Vitamin B12: Toward an Understanding of their Therapeutic Potential

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(2019) "NNMT inhibition reduces lipogenesis and improves insulin sensitivity." Published in Obesity