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In fact, a key parameter omitted in the trials with deferiprone was that the iron chelator was not targeted to the mitochondria, so effectively only a small fraction of the compound delivered would accumulate in the principal site of damage under these conditions

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Dietary Se deficiency is associated with increased nucleotide catabolism and enhances radiation-induced micronuclei formation, while treatment with Se protects against DNA deterioration (41, 149)

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