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1939 Geoffrey Hadfield (18991981), professor of pathology at the University of London, evaluated the histological changes found in the terminal ileum and its related lymph nodes in 20 cases of regional ileitis: The earliest and possibly the specific histological lesion of regional ileitis is lymphadenoid hyperplasia with the formation of non-caseating giant-cell systems in the submucosa

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Tumor volume was calculated as LW 2 , where L is the tumor length, and W is the tumor width

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