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They can occur at any time during a patients treatment course, most commonly in the first 3 months of treatment, but sometimes long after ICI has been discontinued

There are many types of laxatives each works somewhat differently to make it easier to have a bowel movement

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Although 86% of patients experienced cytokine release syndrome, 90% experienced grades 1 to 2 cytokine release syndrome

doi: 10.1016/j.drudis.2014.09.018

2014 Sep;11(3):253-8