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Increased oxidative stress further accelerated aging by raising serum TNF- levels, reducing Sirtuin 6 (Sirt6) expression in long bones, and promoting NF-B acetylation and cathepsin K overexpression and activation

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The corticosubcortical SCAN circuit is ideally situated to integrate motor planning and execution, autonomic and physiological functions, and other relevant internal and external signals 6,7,32,33,53,54 to guide goal-directed behaviour 36,55,56

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More recently, it was identified that ABA INSENSITIVE 4 (ABI4), which is a key factor in the abscisic acid (ABA) signalling pathway, directly binds to the 206 CCAC motif of the VTC2 promoter, repressing the transcription of this gene and decreasing the AsA levels (Yu et al., 2019

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[DOI] [PMC free article] [PubMed] [Google Scholar] 51.Harmon GS, et al

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628 , 345348 (1993) Rosenmund, C., Stern-Bach, Y

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