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The FDA's guidance on mobile medical applications and the EMA's reflection paper on computer systems validation have progressively accommodated regulated mHealth app use in trial contexts, and the 14.1% CAGR reflects growing sponsor confidence in deploying mHealth as a primary participant communication and data collection channel rather than a supplementary convenience feature

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Due to these challenges, an increasing number of studies have recently devoted their efforts towards hostdirected therapies for TB treatment

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This payment adjustment is codified at 42 CFR 412.85 (for operating IPPS payments) and 42 CFR 412.312 (for capital IPPS payments), for claims appropriately containing Z00.6, as described previously, and reflects that the adjustment is also applied for cases involving expanded access use immunotherapy, and that the payment adjustment only applies to applicable clinical trial cases