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209 Elevated ROS levels, along with mtDNA polymerase mutations that cause replication errors, contribute to mtDNA mutations, multiple deletions, and reduced copy numbers, all of which accumulate with age, leading to mitochondrial dysfunction and cell death

Phase 2 clinical trial data published in the New England Journal of Medicine has been widely noted as some of the most significant findings in the metabolic research space in years

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The present data suggest that increasing GSH levels with oral precursor supplementation is a viable intervention to target diabetic oxidative stress directly and could constitute a novel, safe, and inexpensive form of nutritional treatment