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Accessed June 2025

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Its action was linked with Nrf2 activation resulting from the alkylation of Keap1

These observations clearly support the anticancer effects of polyphenols by changes in the cancer cells epigenome [180]

Therefore, a comprehensive synthesis of available evidence is needed to clarify whether non-invasive routes provide efficacy comparable to intramuscular therapy

& Echaniz-Laguna, A