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Infliximab versus ciclosporin for steroid-resistant acute severe ulcerative colitis (CONSTRUCT): a mixed methods, open-label, pragmatic randomised trial

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Anti-inflammatory profile studied in preclinical models

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The body may absorb cyanocobalamin better, while methylcobalamin has a higher retention rate

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Additionally, an intramuscular injection of vitamin B12 is given one week before the first dose and then every 9 weeks thereafter

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