glutathione glutamine synthetase Synthetase: Diverse Regulation and Functions of an Ancient Enzyme Impaired Glutathione Synthesis in Neurodegeneration

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So, we become more easily susceptible to illnesses, our energy levels decrease, we experience more forgetfulness and neurological degeneration, and some cellular processes begin to break down

Given its essential role in the detoxification of lipid hydroperoxides, and its overexpression in most of myeloid malignancies, GPX4 inhibition has emerged as a promising therapeutic strategy to specifically trigger ferroptosis and eradicate myeloid leukemia cells

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Recently, various studies have attempted to discover therapeutic molecular targets to enhance M2 polarization, reduce infarct volume, and improve functional outcomes [13,14,15]