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Besides its regulatory function on cell cycle, the p16 INK4a molecule has also been reported to control intracellular ROS production, as loss of p16 INK4a results in aberrant mitochondrial mass along with elevated mitochondrial membrane potential (m) and ROS (29)

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GK: Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing original draft, Writing review & editing

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Face: This is generally the most responsive area, with the strongest clinical evidence