endogenous deficiency of glutathione Glutathione: Master Antioxidant, Reducing Oxidative Stress, and Detoxification Frontiers | Glutathione and mitochondria

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However, the basic mechanisms still largely unknown

This stress leads to suppression of forkhead box O1 (FoxO1) signaling and subsequent upregulation of thioredoxin interacting protein, inhibition of insulin and SOD-2 expression, re-expression of Neurog3, and -cell dedifferentiation and functional failure

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