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By mediating cystine uptake, SLC7A11 governs rate-limiting GSH production

Since NFIA transcriptionally upregulates IGFBP2 , miR-302b suppression enhances IGFBP-2-dependent oncogenesis both directly, and indirectly through NFIA [44]

More importantly, glutamine metabolism is also regulated by tumor suppressors

It scavenges free radicals and ROS, effectively neutralizing and expelling them before they can cause damage to cellular structures

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In contrast, the knockdown of GPX2 did not affect the expression of chemoresistance proteins but slightly increased the expression of ABCC1 (Supplementary Fig