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These initial studies reported increased NAD + and NAM levels in plasma, and in urine, the excreted NAD + levels increased after 6 h 66 , but it must be noted that these trials utilized small cohorts and short testing periods, and only a minor trend for cognitive improvement was observed 117

A 30 mg vial at a 2.5 mg weekly dose lasts 12 weeks, well beyond the 28-day reconstituted shelf life

Cobalamins are water-soluble B vitamins

A 6mg/mL concentration (30mg vial in 5.0mL) would require a 2mL injection for a 12mg dose, which is within the standard range for subcutaneous administration

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