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doi: 10.1056/NEJMoa1814213 58 HeistRSGuarinoMJMastersGet al

Liver toxicity would require sustained copper intake far exceeding normal use

Copper is an important compound for collagen synthesis, antioxidant defense, and wound healing, while the GHK sequence acts as a carrier that delivers copper into cells where its needed

Therefore, detection and determination of protein-protein interactions is a critical important approach for the characterization of protein functions

Here we demonstrate that acute brain injury induces vascular damage, meningeal cell death, and the generation of reactive oxygen species (ROS) that ultimately breach the glial limitans and promote spread of the injury into the parenchyma

Vascularization is another key requirement for CTE