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When a peptide solution lands on this surface, several things happen simultaneously

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Specifically, dissociation of the SOD1 dimer is a biophysical consequence of either, (i) a potent destabilizing mutation such as A4V, or (ii) glutathionylation of a weak or non-destabilizing mutation such as G93A

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The S2 subsite is also sufficiently deep to accommodate a larger side chain and is lined by the side chains of Lys208, Arg220 and Thr222 from the N-terminal barrel and Phe673 from the C-terminal barrel

Look better with visible refinement