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doi: 10.2174/1381612825666190215121712
The UUO treatment induces the phosphorylation of Smad3, signal transducer and activator of transcription 3 (STAT3), and extracellular signal-regulated kinase 1/2 (ERK1/2) and upregulates their protein expression
J.HuangJ.DronamrajuR.AdamsA
Curr Pharm Des 2014;20:1121-1125
The duration effect suggests GHK-Cu induces cumulative structural changes in dermal architecture where longer treatment allows more complete remodeling supporting ongoing enhanced function without continuous peptide presence
l , Daily running wheel distance during habituation and treatment period
