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Xp11.2 RCC with TFE3 gene fusion has at least 5 fusion partners, including ASPL-TFE3, PSF-TFE3, CLTC-TFE3, PRCC-TFE3 and Nono-TFE3, with the chromosomal rearrangements t(X;17)(p11.2;q25), t(X;1)(p11.2;p34), t(X;17)(p11.2;q23), t(X;1)(p11.2;q21) and inv(X)(p11.2;q12), respectively (10,11)
Therefore, more recent research has shifted the focus to screening a drug that targets the lipotoxicity of individuals with fewer side effects to prevent and treat KOA [10, 11]
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10.3390/molecules22040608
