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Avoid overexerting affected joints during early recovery

In addition, macrophages also release pro-fibrotic molecules such as transforming growth factor- (TGF-), that is crucial in the initiation of the fibrotic process [24, 25]

Whilst one meta-analysis of 24 RCTs found a decrease in the pro-inflammatory markers C-reactive protein (CRP) and interleukin-6 (IL-6), 15 the other (based on 28 studies) found a decrease in interleukin-8 (IL-8) when pooling all data and a decrease in IL-6 in a subset of studies using a dose of 1200 mg NAC per day or less, but no difference in CRP

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Then hormone fluctuations begin

Likewise, the methanolic extract of P