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This process can be compared to the establishment of ploidy in humans, as all hepatocytes are diploid in neonates and approximately 40% of hepatocytes are polyploidy by late teens, these processes all take time

10.1016/j.biopha.2022.112658 9 Al MamunA.HashimotoM.KatakuraM.HossainS.ShidoO

Schaeffer, S

111 SakagamiH.ShengH.OkudairaN.YasuiT.WakabayashiH.JiaJ.et al (2016)

In patients with SURF-1 mutations, symmetrical involvement of the bilateral brainstem and subthalamic nuclei is common, and some patients exhibit basal ganglia abnormalities

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