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FDA has issued several nanotechnology guidance documents emphasizing material characterization, critical quality attributes, and risk-based assessment, while the EMA provides more structured guidance for nanocarriers and liposomal products, including scientific advice for nanoparticle excipients and surface modifications

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doi: 10.1016/S0140-6736(14)60763-7 6 FrisoliMLEssienKHarrisJE