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Defined by hyperandrogenism, ovulatory dysfunction, insulin resistance, and chronic low-grade inflammation, PCOS, a common endocrine disorder in reproductive aged women causes irregular periods, infertility, excess androgens which collectively contributes toward long-term risks for serious conditions like type 2 diabetes, cardiovascular diseases, sleep apnea, depression, endometrial cancer and other reproductive complications underscoring the need for a comprehensive, multifaceted management strategy ( Figure 1 )

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Toxicol Sci 2004;82:37480 [DOI] [PubMed] [Google Scholar] 83.Wolf KK, Wood SG, Hunt JA, Walton-Strong BW, Yasuda K, Lan L, Duan SX, Hao Q, Wrighton SA, Jeffery EH, Evans RM, Szakacs JG, von Moltke LL, Greenblatt DJ, Court MH, Schuetz EG, Sinclair PR, Sinclair JF