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Conversely, patients with TNF- or IL-6 gene variants may benefit from early anti-inflammatory treatments to mitigate inflammation and protect the retina ( Understanding gene-environment interactions is crucial, as factors like diet, exercise, and socioeconomic status can influence DR onset and progression

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In Igri, bicellulars remained 40% across stages IIIII, with multicellular structures at 12% in stage II and 6% in stage III

In the absence of glutamine, or when glutaminolysis is inhibited, cystine starvation and blockage of cystine import fail to induce the accumulation of reactive oxygen species (ROS), lipid peroxidation, and ferroptosis

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