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Yang et al., 2025)

GSH is found predominantly in its reduced form, except in the ER, where it exits mainly as oxidized glutathione (GSSG), GSSG being the main source of oxidizing equivalents to provide the adequate environment necessary for favoring disulfide bond formation and the proper folding of nascent proteins (61)

In LRRK2 knockdown murine microglia, LPS treatment reduces TNF-, inducible nitric oxide synthase, IL-1, and IL-6 mRNA and/or protein levels, indicating LRRK2 positively regulates inflammatory induction (193)

5-HT or NE/dopamine depletion did not decrease mood in healthy controls and slightly lowered mood in healthy controls with a family history of major depressive disorder

To further validate whether RanBPM physically interacts with p21 protein, we performed GST-pull down assay by using the purified recombinant His-RanBPM and GST-p21 proteins