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Liu Y, et al

Gene Ther 20(8):846852

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Although there appear to be few controlled clinical studies in humans, supplements of acetyl-carnitine are reported to improve the cognitive abilities of patients in the milder, early stages of Alzheimer's Disease

Evidence points to both central and peripheral proinflammatory mechanisms working alone or together with neurotoxic molecules, such as NH3.59,60 In turn, hyponatremia, sepsis, gastrointestinal bleeding, and kidney failure precipitate the exogenous production of TNF, which exacerbates HE presentation

A randomised controlled trial comparing duloxetine and acetyl L-carnitine in fibromyalgic patients: preliminary data