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This approach allowed for the continuation of OHCbl therapy or the adjustment of therapy required to improve metabolic control in our patients

This notion is corroborated by the animal investigations where DATS was found to stimulate the expression of various detoxification enzyme genes in normal mice but not in mice lacking the Nrf2 gene (111)

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The ubiquitin-proteasome system (UPS) maintains protein quality control and cellular homeostasis by tagging damaged and misfolded proteins for degradation