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Annu Res Rev Biol 2017;11:1-8 10.9734/ARRB/2016/31711 [DOI] [Google Scholar] 62

The biphasic response suggests possible mechanisms: lower doses (nanogram range) might work through growth factor upregulation and signaling cascade amplification, while higher doses (microgram range) might involve direct receptor activation or substrate provision for cellular repair

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