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Chronic injuries that have been present for months or years generally take longer

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However, it has been reported that IGF-IR is overexpressed in the majority of adult GBMs compared with the normal brain, though the nuclear localization of IGF1R was not analyzed

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6.1 Targeting the synergy between -synuclein aggregation and ferroptosis Iron overload accelerates the formation of toxic -syn oligomers, while aberrant -syn expression disrupts iron metabolism and GSH synthesis, thereby creating a vicious cycle that enhances neuronal susceptibility to ferroptosis (Chen et al., 2025)

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Irisin treatment improved motor function, as evidenced by enhanced performance on the rotarod test, and promoted dopaminergic neuron survival, demonstrated by increased TH-positive cell counts and reduced -synuclein accumulation

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Darby, N

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Category 2 means they cant anymore

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