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[4] Similarly, Rhodiola rosea is traditionally used to fight fatigue and clear the mind. Yet, clinical studies have been small and have several limitations overall, there is scant reliable evidence that Rhodiola or most herbal supplements noticeably improve cognition

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At present, the mechanistic link between TCM or acupuncture, gut microbiota modulation, and post-stroke sleep improvement relies predominantly on indirect or general population data, highlighting an unmet need for PSI-specific RCTs to substantiate these claims (

Notably, lumateperone, an antagonist for D1, D2, D4, and serotonin receptor 2A and transporters (Kumar et al., 2018), improved depressive symptoms in bipolar depression patients in the first clinical trials (Calabrese et al., 2021), although it also showed potential inflammatory effects (El-Haroun et al., 2021)