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This pattern encompasses a multitude of factors, including physiological characteristics, genetic background, and environmental conditions, which are crucial in predicting and intervening against the occurrence of high-altitude illnesses ( 3.1.2.1 AMS individual susceptibility pattern Researchers such as 3.1.2.2 AMS susceptibility in familial patterns Genetic diseases often show higher incidence rates within certain families

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ROS and oxidatively modified macromolecules function as damage-associated molecular patterns (DAMPs), engaging pattern recognition receptors (PRRs) on microglia, including Toll-like receptors (TLRs) and NOD-like receptors (NLRs), to initiate inflammatory cascades ( Microglia, the resident immune cells of the CNS, are tightly regulated under physiological conditions to maintain neural homeostasis