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A previous study reported higher blood CCL5 levels in patients with TS [67]

However, it should be noted that the expression of a methylated gene can be increased when either the coding sequence is hypermethylated or the promoter or transcriptional start site is hypomethylated[130]

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doi: 10.1001/jamaophthalmol.2021.0640, 271

10 Conclusions and future perspectives In conclusion, studying the mechanisms of comorbidity through the perspective of ferroptosis is essential, with GPX4 and Nrf2 being highlighted as critical targets

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