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Glutathione can also be obtained through the diet, particularly from foods rich in sulfur-containing amino acids.L-Glutathione supplements are available and are promoted for several potential health benefits.Benefits L-Glutathione supplementation include:Antioxidant Support: Glutathione is a potent antioxidant that helps neutralize free radicals in the body

Collectively, our findings indicate that in AML cells, GPX4 inhibition induces ferroptosis, which is regulated by mitochondrial lipid redox and ETC.

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As a potent antioxidant and a natural dithiol compound, it performs a crucial role in mitochondrial bioenergetic reactions

Consistently, Rho0 cells, which lack functional ETC, were more sensitive to GPX4 inhibitionmediated mitochondrial lipid peroxidation and ferroptosis than control cells