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Neuroprotective Effect of -Lipoic Acid against A25-35-Induced Damage in BV2 Cells

A DNA repair-independent role for alkyladenine DNA glycosylase in alkylation-induced unfolded protein response

433 On a molecular level, RFE is influenced by the interaction between titin and actin and the stabilization of cross-bridges during and after lengthening contractions

metabolite Ac-LKKTE identified as potentially more active than parent compound Paradoxical finding: Both peptides show biological effects persisting hours to days after administration despite rapid plasma clearance Possible explanations: Tissue retention, active metabolites, or persistent signaling cascade activation Excretion Pathways Limited data exists on excretion for both peptides[22]: Likely renal elimination of peptide fragments Hepatic metabolism may contribute to clearance No accumulation detected in chronic dosing studies (animal models) Combined excretion kinetics have not been characterized in any species The disconnect between short plasma half-lives and prolonged biological effects represents a key area requiring mechanistic clarification for both individual peptides and their combination

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Efficacy and safety of praziquantel for the treatment of human schistosomiasis during pregnancy: a phase 2, randomised, double-blind, placebo-controlled trial