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Moreover, we found that GPX2 KO cells display increased chromatin accessibility at the SRY-Box Transcription Factor 2 ( SOX2 ) and DCLK1 loci compared to WT cells (Supplementary Fig

Interestingly, treatment with insulin, hydrocortisone and ethanol, which induced only GCLC, increased the GSH synthesis capacity by 50 to 100% at the most (Lu et al., 1992b

This spatial and transcriptional heterogeneity suggests that localized ferroptotic events may drive tissue damage by interfering with cartilage repair and intercellular communication

Storage Lyophilized: 20C for long-term storage Reconstituted: 28C (refrigerator) Shelf life after reconstitution: use within 1428 days at 28C Batch / lot Every vial is labeled with a lot number and manufacture date that resolves to a Certificate of Analysis in our public COA Library

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Secondly we compared the metabolic profiles of the gdh3 / gdh3 mutant and wild type when grown in arginine and proline media ( gdh3 -P vs WT-P, gdh3 -R vs WT-R)