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10.1155/2015/151979 [DOI] [PMC free article] [PubMed] [Google Scholar] Aoyama K

A high-dose B12 shot, which is given intramuscularly as prescribed by a doctor, can quickly resolve a deficiency by raising the level of vitamin B12 in the blood

Hence, blockade of inflammation may protect at first, but actually be detrimental to the final outcomes

Additionally, there is little evidence that choline improves memory in elderly individuals without dementia (126)

However, preclinical data does not guarantee human safety

Not all B12 that you eat or take in supplements is absorbed and research indicates that to achieve a sufficient daily dose of B12, you should take at least five to 50 micrograms daily or 1,000 to 2,000 micrograms weekly (Del Bo et al., 2019