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Efficacy and safety of nanoparticle albumin-bound paclitaxel monotherapy after immune checkpoint inhibitor administration for advanced non-small cell lung cancer: a multicenter phase 2 clinical trial

Future studies must better define the molecular context of antioxidant action, including the following: which biomolecules are being protected, the specific radical species targeted, the tissue and subcellular distribution of the antioxidant, and how levels of endogenous antioxidants and reactive oxygen species (ROS) change post-administration (e.g., within the mitochondria)

In general, given the complex functions of mitochondria, any dysfunction may result in abnormal pathological states, contributing to the development of numerous diseases

Immunofluorescence staining similarly revealed that the expression of PHB2, BECN1, and LC3 was significantly decreased in HG of the aged mice compared to HG of the young mice (Fig

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