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Of significance, the decrease in GSH combined with diminished -glutamylcysteine ligase activity in these animals, renders Gclm/ fetal fibroblasts strikingly more sensitive to chemical oxidants (Yang et al., 2002)

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5.2 Renal triple therapy for kidney protection The therapeutic strategy combining RAASi, SGLT2i, and ns-MRAscollectively referred to as Renal Triple Therapy (RTT)offers synergistic, mechanism-based protection in the management of DKD