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The PI3K/Akt pathway plays an important role in synovial inflammation 31

ZFAS1 has been shown to enhance the interaction between the key kinase AMPK and the major regulator of EMT, ZEB1

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Futhermore, in HepG2 cells, GA treatment activated AMPK signaling and reduced mRNA expression of key transcription factors in fatty acid synthesis, including SREBP-1c, LXR, and ACC, as well as fatty acid transporter proteins such as CD36 and FATP2, which mitigated palmitic acid-induced lipid accumulation (Tanaka et al., 2020a)