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developed inhalable dexamethasoneloaded PLGAlipid nanoparticles with surface modification of FcRn peptide, which facilitates transepithelial transport of nanoparticles and subsequent entry into inflammatory cells [58]

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This aberrant SNO can lead to conformational changes and misfolding of the proteins that affect their functions [167]

Produced to pharmaceutical standards (e.g., by Hospira, a Pfizer subsidiary), it comes in 30 mL multiple-dose vials with semi-rigid polyolefin construction designed for repeated needle punctures while maintaining seal integrity

Methods: The study included 30 patients with gout, encompassing individuals with current/historical asymptomatic HU and patients with a confirmed diagnosis of gout according to the ACR/EULAR 2015 criteria