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Front Physiol 12:606931 Yau WW, Singh BK, Lesmana R, Zhou J, Sinha RA, Wong KA, Wu Y, Bay B-H, Sugii S, Sun L (2019) Thyroid hormone (T3) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy

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Ji LL, Hollander J

Initially identified as a CRY1-interacting protein in a high-throughput yeast two-hybrid screen (Rual et al., 2005), TRAF2 was later shown to bind directly to BMAL1, reducing its abundance without affecting CRY1 levels ( TRAF2 overexpression enhances BMAL1 ubiquitination and proteasomal degradation, thereby attenuating E-box-mediated transcription and dampening PER1 oscillations ( 4.1.18 UBE3A UBE3A, an E3 ubiquitin ligase previously implicated in Angelman syndrome and HPV-related tumorigenesis, has recently emerged as a conserved regulator of the circadian clock through its post-translational control of BMAL1 stability (Gossan et al., 2014

The rise in obesity creates additional concerns it substantially increases the risk of non-alcoholic fatty liver disease, which impairs the livers ability to detoxify effectively and creates a dangerous compounding cycle

Characterization of glucose-related metabolic pathways in differentiated rat oligodendrocyte lineage cells
