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Its antiinflammatory properties suppress microglial and astrocyte activation, inhibit NFB signaling, and lower proinflammatory cytokines such as IL1 and TNF, thereby alleviating chronic neuroinflammation that exacerbates AD pathology (McGrattan et al

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Notably, the study reports a persistent upregulation of CCL11 in peripheral leukocytes in patients with VCD

We found remarkably upregulated expression of the marker genes of inflammatory indicators ( TNF- , IL-6 , IL-1 , IL-23 , and Nfb1 ), chemokine CCL2 , and toll-like receptor 4 ( TLR4 , an important pathogen recognition receptor that recognizes mainly LPS of Gram-negative bacteria) in S-amlodipine-treated rats compared with control rats (Figure 2(gh))

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