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History & Evolution Biosynthesis & dietary uptake Methylmalonic acid and the microbiome Methylmalonic acid and vitamin B12 deficiency Methylmalonic acid and neurology Methylmalonic acid and 5P medicine References History & Evolution 1963: First clinical description in pernicious anemia | 1967: Discovery of methylmalonic aciduria | 1968: Vitamin B12 responders in methylmalonyl-CoA deficiency | 1993: Methylmalonic acid (MMA) as biomarker for vitamin B12 deficiency Methylmalonic acid (MMA) was first linked to human disease in 1963, when researchers observed elevated urinary levels in patients with pernicious anemia (Barness et al

Patients might lack vitamins and minerals like vitamin B12, iron, calcium, and vitamin D

Maintenance doses are typically given monthly, but some people may require injections every few months

Here in this prespecified analysis, we examined effects of semaglutide on weight and anthropometric outcomes, safety and tolerability by baseline body mass index (BMI)