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Among the central alterations found in fibromyalgia are irregularities in monoaminergic neurotransmission, leading to increased levels of some excitatory neurotransmitters (known as algesic mediators) such as glutamate and substance P [127,128]

Cell 57 , 957970 (2015)

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Both JNK and ERK mediate HCC cell migration by phosphorylating paxillin at serine residues, which is called an HGF-induced focal adhesion signaling molecule (Kermorgant et al., 2004) to direct fluctuating JNK and paxillin signaling pathways which involve HCC cell migration (Wu et al., 2015) and may be also a specific and safe target for treating HCC patients

Metformin , the first-line type 2 diabetes drug and an AMPK activator, has cognitive data that are observational and inconsistent, and it lowers BDNF, a growth factor the brain relies on and that exercise raises, which is a reason for caution in a healthy brain

J Am Soc Nephrol 2012;23:854867