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Gut microbiota changes and colorectal cancer The term microbiome encompasses the community of microorganisms in a specific habitat, their structural elements, metabolites, and environmental conditions (Berg et al., 2020)

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Despite advances in chemotherapy, radiotherapy, and targeted therapies, challenges such as poor drug accumulation, systemic toxicity, and multidrug resistance persist, partly due to elevated intracellular GSH levels that neutralize reactive therapeutics and reduce treatment response