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Therefore, activity of the TCA cycle is likely to influence cellular processes by mechanisms beyond just the production of ATP from the electron transport chain

By week 16, a larger proportion of AXA1125-treated subjects (3540%) than those in the placebo group (825%) reached clinically relevant thresholds for MRI-PDFF reductions of 30%, ALT reductions of 17 IU/L, and cT1 reductions of 80 ms

doi: 10.1182/blood-2009-01-199919 121 SethupathyS.SathiyamoorthiE.KimY

Tert-butyl hydroproxide (TBHP) Tert-butyl hydroproxide is a hepatotoxic agent which in case of exposure stimulates rapid oxidation of intracellular GSH, and pyridine nucleotides, as well as leakage of cytosolic enzymes (83, 84)