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In addition to obesity, IR and diabetes, TMAO is also reported associated with other metabolic dysregulations that related to MAFLD, including dyslipidemia ( The Underlying Mechanisms of TMAO in the Development of MAFLD Although TMAO has been shown to be linked to MAFLD, the molecular mechanisms of TMAO remain obscure

It can indicate gross contamination (unexpected colors)
Young, J

The role of the carnitine system in human metabolism, link: 14

TIPS is contraindicated in patients with heart failure or severe pulmonary hypertension because it can abruptly increase preload to the heart
