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The microbiome-derived metabolite TMAO drives immune activation and boosts responses to immune checkpoint blockade in pancreatic cancer

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Therefore, more randomized controlled trials are required in this regard

(B) The flavin-containing monooxygenase (FMO) enzyme, which is expressed by the FMO gene in the liver, kidney, and other tissues, converts the microbiome-derived TMA molecule into TMAO once it enters the host's circulation and reaches hepatocytes (43, 47, 48)