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Effect of pharmacological modulators of NO/cGMP/K ATP signaling pathway on nicorandil mediated antinociceptive effect on cold allodynia induced by acetone in CCI rats Nicorandil administration (150 mg/kg, twice, 2 h interval, PO) significantly alleviated acetone cold allodynia at all tested time intervals (1.5, 3.5, 5.5 and 7.5 h after first nicorandil dose) manifested as significant decrease in the cumulative scores (P 0.05) (Fig