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332 Thus, the true cytoplasmic metal inducer of a ZntR may well be dependent upon the composition of the intracellular buffering milieu, which thus impacts its set-point K d S for a specific metal (Figure 8), perhaps in response to its environmental niche in which an organism resides

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Disclosure The authors report no conflicts of interest in this work

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Both channels are calcium-permeable and they may form a complex on the plasma membrane of sensory neurons: in this way TRPV1 can influence TRPA1 with voltage-current relationships and enhancing its open probability at negative potentials