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[ 88 , 94 , 472 , 474 , 475 ] Keap1, the most validated target for NRF2 activation, is a redox sensor containing several cysteine residues, whose oxidation or modification compromises either dimeric structure formation or combination to ubiquitin ligase, resulting in NRF2 protein release and nuclear import

While current studies highlight promising therapeutic avenues, future research should focus on validating long-term safety and efficacy through larger cohorts, while also examining the functional stability of transplanted cells, their integration with host neural circuits, and any potential off-target or neuroimmune effects to ensure clinical translatability

Research shows that women who take both supplements experience better pregnancy outcomes compared to those who do not

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